NIMU-100 + PARA-325 + CAFF.-25 + PHENYLPHERINE-10 + CETRIZINE-5
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic antipyretic properties. It selectively inhibits cyclooxygenase-2 (COX-2). It is indicated as second line treatment for acute pain, symptomatic treatment of painful osteoarthritis and primary dysmenorrhoea.
It is classified as a mild analgesic. It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. Though paracetamol is used to treat inflammatory pain, it is not generally classified as NSAIDs because it exhibit only weak anti-inflammatory activity.
Cetirizine is a second-generation antihistamine used in the treatment of hay fever, allergies, Angioedema, and Urticaria. It is a major metabolite of hydroxyzine and a racemic selective H1 receptor antagonist.
It is a sympathomimetic vasoconstrictor that has been used as a nasal decongestant. Phenylephrine constricts the blood vessels in the nasal mucous membranes and allows the air passages to open up. It is relatively selective alpha-adrenoceptor agonist. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors. At therapeutic doses, it does not cause significant stimulation of the central nervous system.
#Caffeine is a central nervous system (CNS) stimulant. Caffeine enhances the analgesic activity of Paracetamol.
Combination is not recommended for:
• Patient with known hypersensitivity to the combination or any of the ingredients of the combination.
• Contradicted in pregnancy and breast feeding
• Relief of nasal and sinus congestion.
• Relief of allergic symptoms of the nose or throat due to upper respiratory tract allergies.
• Relief of sinus pain and headache.
• Adjunct with antibacterials in sinusitis, tonsillitis, and otitis media
• Epigastric pain
• skin rashes
20 X 10